Table 3.
Baseline characteristics among all patients with CD by prior number of MOAs (cohort 2).
| Characteristics among patients with CD | All CD patients N = 2594 |
≤1 MOA N = 1220 |
2 MOAs N = 1062 |
3 MOAs N = 312 |
P-value |
|---|---|---|---|---|---|
| Length of pre-AT period [years], mean ± SD | 5.9 ± 3.2 | 5.4 ± 3.1 | 6.1 ± 3.2 | 7.2 ± 3.2 | <.0001 |
| Age at the index date, mean ± SD | 40.7 ± 14.4 | 38.9 ± 14.2 | 41.9 ± 14.3 | 44.1 ± 14.1 | <.0001 |
| Female, n (%) | 1401 (54.0) | 648 (53.1) | 580 (54.6) | 173 (55.5) | .6671 |
| Last CD disease location category in the baseline, n (%) | .0554 | ||||
| Large intestine | 430 (17.1) | 184 (15.8) | 193 (18.5) | 53 (17.3) | |
| Small and large intestine | 532 (21.1) | 251 (21.5) | 211 (20.2) | 70 (22.8) | |
| Small intestine | 768 (30.5) | 374 (32.1) | 322 (30.8) | 72 (23.5) | |
| Unspecified | 787 (31.3) | 357 (30.6) | 318 (30.5) | 112 (36.5) | |
| Insurance, n (%) | .0533 | ||||
| Commercial | 2530 (97.5) | 1199 (98.3) | 1027 (96.7) | 304 (97.4) | |
| Medicare | 64 (2.5) | 21 (1.7) | 35 (3.3) | 8 (2.6) | |
| Baseline CCI, mean ± SD | 0.7 ± 1.2 | 0.7 ± 1.1 | 0.8 ± 1.3 | 0.9 ± 1.3 | .0015 |
| Number of treated days prior to index date, mean ± SD | 419.3 ± 677.1 | 120.9 ± 310.5 | 559.9 ± 700.7 | 1107.9 ± 936.6 | <.0001 |
| IBD disease complications, n (%) | |||||
| Fistula | 272 (10.5) | 153 (12.5) | 91 (8.6) | 28 (9.0) | .0055 |
| Intestinal abscess | 204 (7.9) | 107 (8.8) | 77 (7.3) | 20 (6.4) | .2411 |
| Intestinal stricture | 334 (12.9) | 167 (13.4) | 135 (12.7) | 32 (10.3) | .2655 |
| Perianal abscess | 168 (6.5) | 99 (8.1) | 56 (5.3) | 13 (4.2) | .0048 |
| Stoma | 23 (0.9) | 9 (0.7) | 10 (0.9) | 4 (1.3) | .5580 |
| EIMs, n (%) | 170 (6.6) | 75 (6.2) | 81 (7.6) | 14 (4.5) | .1053 |
| Baseline presence of IBD-related ED visit, n (%) | 472 (18.2) | 185 (15.2) | 226 (21.3) | 61 (19.6) | .0006 |
| Baseline presence of IBD-related hospitalization, n (%) | 461 (17.8) | 213 (17.5) | 199 (18.7) | 49 (15.7) | .4334 |
Abbreviations: AT, advanced therapy; CCI, Charlson Comorbidity Index; CD, Crohn’s disease; ED, emergency department; EIM, extraintestinal manifestation; IBD, inflammatory bowel disease; MOA, mechanism of action; SD, standard deviation.