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. 2024 Aug 28;81(1):373. doi: 10.1007/s00018-024-05400-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — The sensory nerve induces the migration of DPSCs through CGRP-Ramp1 signaling. aPrimary culture of neurons from rat trigeminal ganglion and collection of conditioned medium.bCell mobility isassessed via wound healing assays, and the chemotactic response to CGRP was evaluated using transwell assays.c-eRepresentative images and quantified results of wound healing and transwell migration assays in Sham groups stimulated with trigeminal ganglion conditioned medium (TG-CM), calcitonin gene-related peptide (CGRP, 50 ng/ml), TG-CM plus BIBN4096, and BINB4096.Scale bar = 100 μm.(*P< 0.05, **P< 0.01, ***P< 0.001, n = 3). f-hRepresentative images and quantified results of wound healing and transwell migration assays in IANX groups stimulated with trigeminal ganglion conditioned medium (TG-CM), calcitonin gene-related peptide (CGRP, 50 ng/ml), TG-CM plus BIBN4096, and BINB4096. Scale bar = 100 μm. (*P< 0.05, **P< 0.01, ***P< 0.001, n = 3)