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. 2024 Aug 28;81(1):373. doi: 10.1007/s00018-024-05400-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 5 — The sensory neuropeptide CGRP promotes collective cell migration by tuning intercellular junctions and cell polarity. a Immunofluorescence staining of CDC42 (green) and F-actin (red) in the DPSCs of the Sham and IANX groups. Scale bar, 100 μm. b Quantified results from a. Asterisks (*) and pound signs (^#) mark statistical differences compared with the Sham group and the same group without CGRP treatment, respectively. (*^/#P < 0.05, **^/##P < 0.01, ***^/###P < 0.001, n = 15). c Immunofluorescence staining of N-cadherin (green) and F-actin (red) in the DPSCs of the Sham and IANX groups. Scale bar, 100 μm. d Quantified results from a. Asterisks (*) and pound signs (#) mark statistical differences compared with the Sham group and the same group without CGRP treatment, respectively. (*^/#P < 0.05, **^/##P < 0.01, ***^/###P < 0.001, n = 15). e Images showing p53 staining (red) and nuclei (blue) at the wound edge of DPSCs in Sham and IANX groups. f Quantified results from e. Asterisks (*) and pound signs (#) mark statistical differences compared with the Sham group and the same group without CGRP treatment, respectively (*^/#P < 0.05, **^/##P < 0.01, ***^/###P < 0.001, n = 15)