Fig. 6.

Sensory nerves promote pulp healing via the CGRP-RAMP1 axis by facilitating collective migration of DPSCs. a Immunofluorescence staining of Stro-1 (red) and CD146 (green) in the pulp close to the injury of the Sham group at 3 d. Yellow arrows indicate dental pulp injury sites. Scale bar = 100 μm. b Immunofluorescence staining of Stro-1 (red) and CD146 (green) in the pulp close to the injury of the IANX group at 3 d. Yellow arrows indicate dental pulp injury sites. Scale bar = 100 μm. c MicroCT analysis and HE staining of the Sham group at 14 d. Scale bar = 1 mm. d MicroCT analysis and HE staining of the IANX group at 14 d. MicroCT scale bar = 1 mm; HE scale bar = 100 μm. e Quantification of the number calcified clusters of MicroCT in c (**P < 0.01, ns indicates P ≥ 0.05, n = 3). f The percentage of the calcified area of the total pulp area (%) of MicroCT in c (*P < 0.05, ns indicates P ≥ 0.05, n = 3). g Quantification of the calcified clusters number of MicroCT in d (*P < 0.05, ns indicates P ≥ 0.05, n = 3). h The percentage of the calcified area of the total pulp area (%) of MicroCT in d (*P < 0.05, ns indicates P ≥ 0.05, n = 3)