Figure 2.

Schematic representation of recurrent RET mutations and rearrangements in cancer. (A) Structure of the RET protein reporting the most common mutations identified in cadherin-like repeats domains (CLDs), cystein-rich domain (CRD), transmembrane domain (TM) and tyrosine kinase domain (TKD). (B) RET fusions containing the most common upstream gene partners characterized by an oligomerization domain (OD) and different break-point regions dependent on the exon (E) involved in the generation of the chimeric junction.