Table. Persistent Poverty and Rurality and the Risk of EO-CRC Death by Age at Diagnosis.
| Age group | Rurality | HR (95% CI) for rurality within strata of povertye | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No | Yes | ||||||||||
| No. (%)a | HR (95% CI)b,c | HR for poverty within strata of rurality (95% CI)f | No. (%)a | HR (95% CI)b,c | HR for poverty within strata of rurality (95% CI)d | ||||||
| Patients | 5-y CRC survival | Patients | 5-y CRC survival | ||||||||
| No | Yes | No | Yes | ||||||||
| All age groups | |||||||||||
| No persistent poverty (n = 51 720) | 46 566 (90.0) | 13 128 (28.2) | 33 438 (71.8) | 1 [Reference] | 1.08 (1.02-1.14) | 5154 (10.0) | 1578 (30.6) | 3576 (69.4) | 1.16 (1.11-1.22) | 1.11 (1-1.24) | 1.16 (1.1-1.22) |
| Persistent poverty (n = 6480) | 5134 (79.2) | 1720 (33.5) | 3414 (66.5) | 1.08 (1.02-1.14) | 1346 (20.8) | 446 (33.1) | 900 (66.9) | 1.29 (1.18-1.42) | 1.2 (1.08-1.33) | ||
| 20 to 29 years | |||||||||||
| No (n = 2859) | 2578 (90.2) | 658 (25.5) | 1920 (74.5) | 1 [Reference] | 1.07 (0.87-1.31) | 281 (9.8) | 80 (28.5) | 201 (71.5) | 1.35 (1.06-1.71) | 0.82 (0.53-1.28) | 1.35 (1.06-1.71) |
| Yes (n = 442) | 367 (83.0) | 118 (32.2) | 249 (67.8) | 1.07 (0.87-1.31) | 75 (17.0) | 27 (36.0) | 48 (64.0) | 1.11 (0.75-1.63) | 1.03 (0.67-1.58) | ||
| 30 to 39 years | |||||||||||
| No (n = 10 875) | 9857 (90.6) | 2715 (27.5) | 7142 (72.5) | 1 [Reference] | 1.03 (0.92-1.16) | 1018 (9.4) | 324 (31.8) | 694 (68.2) | 1.26 (1.12-1.42) | 1.2 (0.95-1.53) | 1.26 (1.12-1.42) |
| Yes (n = 1330) | 1065 (80.0) | 357 (33.5) | 708 (66.5) | 1.03 (0.92-1.16) | 265 (19.9) | 85 (32.1) | 180 (67.9) | 1.51 (1.22-1.88) | 1.47 (1.16-1.87) | ||
| 40 to 49 years | |||||||||||
| No (n = 37 986) | 34 131 (89.9) | 9755 (28.6) | 24 376 (71.4) | 1 [Reference] | 1.09 (1.02-1.16) | 3855 (10.1) | 1174 (30.5) | 2681 (69.6) | 1.12 (1.06-1.19) | 1.13 (0.99-1.27) | 1.12 (1.06-1.19) |
| Yes (n = 4708) | 3702 (78.6) | 1245 (33.6) | 2457 (66.4) | 1.09 (1.02-1.16) | 1006 (21.4) | 334 (33.2) | 672 (66.8) | 1.26 (1.13-1.41) | 1.16 (1.03-1.31) | ||
Abbreviations: CRC, colorectal cancer; EO-CRC, early-onset colorectal cancer; HR, hazard ratio.
a
Row percentages were used.
b
Models were adjusted for patient demographics (gender, race, marital status at diagnosis), year of diagnosis, tumor characteristics (tumor grade, tumor stage, primary site), and initial treatment modality (surgery, radiation, chemotherapy).
c
Reference group is rural = No; poverty = No.
d
Reference group is rural = No.
e
Reference group poverty = No.