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PSP partly inactivated TLR4/NF-κB signaling and significantly inhibited NLRP3/ASC/caspase-1/IL-1β signaling pathway in the prefrontal cortex of CRS-induced mice (n = 6). (A) TLR4. (B) pNF-κB/NF-κB ratio. (C) NLRP3. (D) ASC. (E) Cleaved caspase-1. (F) Pro IL-1β. (G) Mature IL-1β. N: normal; C: CRS; F: fluoxetine; L: 100 mg/kg PSP; M: 200 mg/kg PSP; H: 400 mg/kg PSP. # p < 0.05 vs. normal group. * p < 0.05 and ** p < 0.01 vs. CRS group.
