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. 2024 Aug 20;16(16):2358. doi: 10.3390/polym16162358

Figure 5.

Figure 5

PSP treatment reversed CRS-induced prefrontal cortex microglial hypertrophy and hyper-ramification (n = 5). (A) Representative 3D reconstructions of microglia show increased size and complexity in the CRS group compared to the control, with PSP treatment reducing these changes. Scale bar: 5 μm. (B–J) Quantitative analysis: CRS significantly increased microglial area, length, volume, full branch depth, branch points, and Sholl intersections. PSP treatment significantly reduced area, volume, and Sholl intersections, with trends towards normalization in other parameters. These results suggest that PSP mitigates CRS-induced microglial hypertrophy and hyper-ramification, restoring more normal morphology. # p < 0.05, ## p < 0.01 and ### p < 0.001 vs. normal group. * p < 0.05 and ** p < 0.01 vs. CRS group.