Figure 7.

PSP partly increased microglial BDNF expression in the prefrontal cortex and enhanced neurogenesis in the DG of CRS-induced mice. (A) Representative immunofluorescence staining, BDNF (green) in microglia (Iba-1, red) with DAPI-stained nuclei (blue). (B) Quantification showing a significant decrease in relative BDNF fluorescence intensity in the CRS group that is partially reversed by PSP. (C) Representative immunofluorescence staining presents DCX staining to visualize newborn neurons in the DG. (D) Quantification showing the number of newborn neurons per DG. Within Iba-1 means the signal of the target protein was merged by the signal of the Iba-1 constructed surface by Imaris. Merge means blue, red, and green signals overlaying. ^## p < 0.01 and ^### p < 0.001 vs. normal group. ** p < 0.01 vs. CRS group.