Table 2.
Descriptive statistics for selected parameters during the standard of care (SOC) and once-daily dosing (SID) Trials. Cats (n = 13) received SOC treatment for chronic kidney disease on SOC Days 0 through 56, and then SOC in addition to 500 mg of Renaltec orally SID on SID Days 0 through 56. Data are displayed as median (range).
| Laboratory Reference Range | SOC Day 0 | SOC Day 28 | SOC Day 56 (SID Day 0) | SID Day 28 | SID Day 56 | |
|---|---|---|---|---|---|---|
| Weight a,b (kg) | - | 4.0 (3.3–4.6) | 3.9 (3–4.6) | 3.9 (3.1–4.5) | 3.9 (3–4.5) | 3.8 (3.1–4.4) |
| BCS | - | 6.0 (5–7) | 5 (5–7) | 5 (5–6) | 5 (5–7) | 5 (5–7) |
| MCS | - | 1 (0–2) | 1 (0–2) | 1 (1–2) | 1 (1–2) | 1 (1–2) |
| HCT (%) | 33.6–49 | 35.7 (28.2–43.6) | - | 36.5 (27.2–40.1) | - | 35.7 (27.4–39.5) |
| BUN b,d (mg/dL) | 18–35 | 22 (18–35) | - | 22 (17–37) | - | 24 (20–44) |
| Creatinine b,d (mg/dL) | 0.7–1.8 | 1.9 (1.5–4.0) | - | 2.0 (1.6–4.0) | - | 2.1 (1.6–4.7) |
| Phosphorous (mg/dL) | 2.8–5.9 | 3.6 (2.8–4.4) | - | 3.5 (2.4–4.5) | - | 3.4 (2.4–4.6) |
| Bicarbonate (mmol/L) | 15–23 | 16 (12–20) | - | 16 (10–17) | - | 17 (14–19) |
| Anion gap b,d (mmol/L) | 19–29 | 22 (18–26) | - | 23 (18–30) | - | 20 (17–24) |
| Potassium (mmol/L) | 3.6–5.3 | 4.4 (3.6–4.9) | - | 4.6 (3.7–5.2) | - | 4.6 (3.7–5.0) |
| UPC | <0.20 | 0.12 (0.02–0.20) | - | 0.11 (0.05–0.30) | - | 0.10 (0.02–0.50) |
| BP (mmHg) | 100–160 | 156 (107–184) | - | 142 (116–202) | - | 137 (108–170) |
| IDS (ng/mL) c | - | 2012 (617–5827) |
1780 (1015–4682) |
1652 (1257–4119) |
1417 (664–3856) |
1513 (1157–5479) |
| pCS (ng/mL) c | - | 10,422 (5143–47,316) |
8535 (308–37,815) |
12,720 (268–34,609) |
7604 (263–26,575) |
8520 (290–34,114) |
| Average of SOC Days 0, 28, 56 | Average of SID Days 28, 56 | |||||
| IDS (ng/mL) | - | 1800 (1030–4876) | 1592 (944–4669) | |||
| pCS (ng/mL) | - | 10,141 (1906–39,913) | 6861 (277–30,345) | |||
Abbreviations: BCS, body condition score; MCS, muscle condition score; HCT, hematocrit; BUN, blood urea nitrogen; UPC, urine protein–creatinine ratio; BP, blood pressure; IDS, indoxyl sulfate; pCS, p-cresol sulfate. Superscript letters denote significant differences between time points (p < 0.05).a SOC Day 0 to SOC Day 28. b SOC Day 0 vs. SOC Day 56. c SOC Day 56 vs. SID Day 28. d SOC Day 56 vs. SID Day 56.