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. 2024 Jul 3;18(4):101376. doi: 10.1016/j.jcmgh.2024.101376

Figure 1.

Figure 1

Upregulation of PRC2 regulates gastric tissue aging. (A and B) Downregulated ICC makers (KIT and ANO1 protein) and upregulated EZH2 protein and increased H3K27me3 levels in gastric tissues of klotho relative to WT mice and in old mice (22–24 months old) compared with young control animals (8–10 weeks old). The klotho and WT mice were used between 60 and 70 days of age. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a loading control. (C and D) Age-associated downregulation of KIT and ANO1 and upregulation of EZH2 protein and H3K27me3 levels in gastric muscles of patients between 28 and 68 years of age in (C) men and (D) women.