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. 2024 Jul 3;18(4):101376. doi: 10.1016/j.jcmgh.2024.101376

Figure 6.

Figure 6

EPZ6438 treatment restored reduced food intake and impaired body weight gain without significantly affecting insulin secretion in klotho mice. EPZ6438 treatment restored reduced food intake and impaired body weight gain of klotho mice. Restoration of reduced food intake (A) and body weight gain (B and C) of klotho mice by EPZ6438 (EPZ) treatment (n = 27/group). (D) Reduced serum insulin levels in klotho mice were not alleviated by EPZ6438 treatment (n = 8/group). Statistical significance was determined using Kruskal-Wallis 1-way analysis of variance (on ranks). ∗P < .05, ∗∗∗P < .001, ∗∗∗∗P < .0001. ns, not significant.