Table 2.

Parameters of Gastric Slow Waves in WT, Veh-treated klotho Mice and EPZ-Treated klotho Mice

Region	Parameter	WT Veh		klotho Veh		klotho EPZ		P value (WT Veh vs klotho Veh)
Corpus	RMP, mV	-55.09 ± 2.397	[-65.17; -54.61; -48.19]	-56.06 ± 2.178	[-62.29;-57.74;-50.01]	-55.06 ± 2.064	[-62.62;-55.3;-47.63]	.9485
	Frequency, cycles minˆ-1	7.114 ± 0.8207	[3.511; 7.175; 9.186]	5.797 ± 0.8511	[2.511; 4.729; 7.000]	5.783 ± 0.6468	[3.542; 4.835; 7.275]	.4626
	Amplitude, mV	10.43 ± 0.8029	[7.233; 11.04; 13.26]	12.03 ± 1.503	[6.652; 9.555; 14.57]	10.35 ± 0.9979	[6.082; 9.827; 13.980]	.5969
	Peak voltage, mV	-44.65 ± 2.163	[-52.50;-45.73;-37.29]	-44.03 ± 1.899	[-51.90; -43.10; -40.47]	-44.71 ± 1.926	[-51.10;-45.80;-39.53]	.9736
Antrum	RMP, mV	-53.47 ± 4.565	[-64.54; -54.33; -45.90]	-61.84 ± 4.221	[-69.55; -66.33; -51.29]	-44.79 ± 2.035	[-52.64; -42.27; -36.06]	.2838
	Frequency, cycles minˆ-1	6.124 ± 0.8831	[3.853; 5.280; 8.457]	6.342 ± 0.7499	[5.396; 6.881; 7.578]	6.557 ± 0.5425	[5.269; 6.172; 8.993]	.9827
	Amplitude, mV	9.892 ± 2.067	[6.493; 7.488; 16.46]	4.910 ± 1.403	[3.062; 3.958; 6.719]	6.7 ± 0.8776	[3.292; 6.229; 10.16]	.0895
	Peak voltage, mV	-43.58 ± 3.414	[-52.51; -43.61; -38.41]	-56.93 ± 3.604	[-65.51; -58.04; -48.23]	-38.09 ± 1.895	[-43.74; -39.30; -30.70]	.0197

NOTE. Impalements were obtained from intact corpus + antrum tissue, demarcated using fine copper wire. Data are mean ± standard error of the mean and [interquartile range + median] from WT (corpus: n = 5 and n = 7 recordings; antrum: n = 9 mice and n = 24 recordings), klotho (corpus: n = 3 and n = 6 recordings; antrum: n = 10 mice and n = 26 recordings), and klotho EPZ (corpus: n = 6 and n = 17 recordings; antrum: n = 9 mice and n = 26 recordings) mice. P values were determined using Kruskal-Wallis 1-way analysis of variance (on ranks).

EPZ, EPZ6438; RMP, resting (diastolic) membrane potential; Veh, vehicle; WT, wild-type.