Table 1.

Averaged kinetic characteristics of the current traces evoked by sustained (4 min) applications of saturating agonist concentrations in oocytes expressing WT m5-HT₃AR (100 μM 5-HT), WT ZAC (10 mM Zn²⁺), WT hα₁ GlyR (100 μM Gly) and the chimeric receptors m5-HT₃A/ZAC (3 μM 5-HT) and ZAC/hα₁-Gly (30 μM Zn²⁺). Δt_{start-to-peak}: time from the start of the agonist application until peak current is reached (in s); Δt_{peak-to-plateau} (WT hα₁ GlyR and ZAC/hα₁-Gly): time from the peak current to plateau is reached (in s); I_{residual, 4 min}: residual current after 4 min of agonist application (in % of peak current). Data are given as mean ± S.E.M. values with the number of traces (n) upon which the respective data are based. Representative traces are given in Fig. 2C and Fig. 3C.

Receptor	Δtstart-to-peak (s)	Δtpeak-to-plateau (s)	Iresidual, 4 min (% of Ipeak)	n
WT m5-HT3AR	2.1 ± 0.4	–	~0 (none)	7
m5-HT3A/ZAC	46 ± 7.2	–	67 ± 6	5
WT ZAC	4.8 ± 0.5	–	21 ± 3	8
ZAC/hα1-Gly	10 ± 1.9	56 ± 3.8	63 ± 6	8
WT hα1 GlyR	2.7 ± 0.3	52 ± 5.9	51 ± 5	7