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. 2024 Aug 2;16(8):1030. doi: 10.3390/pharmaceutics16081030

Figure 5.

Figure 5

Sheep pharmacokinetics of ENG/EE after 92 days of CLIPHIGH IVR administration. (A) Study design of a 92-day PK study with CLIPHIGH IVR in female sheep. ENG/EE concentrations in sheep (n = 3 sheep that underwent the entire 92-day study) in (B) plasma, (C) vaginal tissue and (D) vaginal fluids from CLIPLOW IVR, CLIPHIGH IVR and NuvaRing. Each curve represents the average ± standard deviation. Dashed lines indicated the last concentration (day 21) of ENG (dashed green line) and (dashed blue line) from the NuvaRing sheep study extended to 92 days for comparative purposes only. Individual replicates for sheep that underwent the 92-day study duration with CLIPHIGH IVR are shown in Figure S2. Individual replicates for CLIPLOW IVR and NuvaRing are shown in Figure S1.