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Quantification of residual drug and estimation of in vivo release rates. (A) Residual drug ENG/EE after CLIPHIGH IVR removal at days 30, 60 and 92 post-administration. (B) % ENG/EE released in vivo after IVR removal. (C) Estimation of ENG and EE in vivo release rates based on residual drug content after IVR removal. Data represent average ± standard deviation for n = 2 sheep for day 30 and n = 3 sheep for days 60 and 92.
