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. 2024 Aug 2;16(8):1030. doi: 10.3390/pharmaceutics16081030

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Sheep safety analysis for CLIP_HIGH IVR. Histological images of vaginal biopsies from sheep administered CLIP_HIGH IVR (with higher magnification insert) at (A) day 0, (B) day 1, (C) day 3, (D) day 7, (E) day 14, (F) day 21, (G) day 30, (H) day 60, (I) day 77 and (J) day 92, and (K) day 3 post-IVR removal and (L) day 7 post-IVR removal. Red arrowheads denote examples of eosinophils. Black arrows denote parakeratosis. Scale bar = 50 µm. (M) Histological scoring summary based on H&E images for 92 days. Individual scores from each sheep are presented in Figures S5–S7. Day 0 represents the baseline with no IVR use.