Table 5.
Titers of neutralizing antibodies in guinea pig sera.
| Day | Vaccine | Immunofluorescence Inhibition (Positive/Sample) | −log2 |
p Value |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1/8 | 1/16 | 1/32 | 1/64 | 1/128 | 1/256 | 1/512 | 1/1024 | 1/2048 | 1/4096 | 1/8192 | 1/16384 | ||||
| 0 | Capped | 4/4 | 4/4 | / | / | / | / | / | / | / | / | / | / | <3 | |
| 4/4 | 4/4 | / | / | / | / | / | / | / | / | / | / | <3 | |||
| 4/4 | 4/4 | / | / | / | / | / | / | / | / | / | / | <3 | |||
| Capless | 4/4 | 4/4 | / | / | / | / | / | / | / | / | / | / | <3 | ||
| 4/4 | 4/4 | / | / | / | / | / | / | / | / | / | / | <3 | |||
| 4/4 | 4/4 | / | / | / | / | / | / | / | / | / | / | <3 | |||
| 28 | Capped | / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 2/4 | 2/4 | 4/4 | / | 11.5 | 0.10 |
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 1/4 | 2/4 | 4/4 | / | 11.6 | |||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 1/4 | 4/4 | 4/4 | / | 11.2 | |||
| Capless | / | 0/4 | 0/4 | 0/4 | 0/4 | 2/4 | 2/4 | 4/4 | 4/4 | / | / | / | 8.5 | ||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 3/4 | / | / | / | 10.7 | |||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 2/4 | 4/4 | 4/4 | 4/4 | / | / | / | 8.0 | |||
| 35 | Capped | / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 1/4 | 1/4 | 14.0 | 0.09 |
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 2/4 | 3/4 | 13.2 | |||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 2/4 | 14.0 | |||
| Capless | / | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 2/4 | 2/4 | 4/4 | 4/4 | 4/4 | 4/4 | 9.3 | ||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 3/4 | 4/4 | 12.5 | |||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 3/4 | 4/4 | 4/4 | 4/4 | 4/4 | 4/4 | 8.7 | |||
| 42 | Capped | / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 3/4 | 3/4 | 4/4 | 11.7 | 0.04 |
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 3/4 | 4/4 | 12.7 | |||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 1/4 | 3/4 | 13.3 | |||
| Capless | / | 0/4 | 0/4 | 0/4 | 0/4 | 2/4 | 1/4 | 4/4 | 4/4 | 4/4 | 4/4 | 4/4 | 9.0 | ||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 1/4 | 4/4 | 4/4 | 4/4 | 11.2 | |||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 3/4 | 4/4 | 4/4 | 4/4 | 4/4 | 4/4 | 8.7 | |||
| 49 | Capped | / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 2/4 | 4/4 | 13.0 | 0.15 |
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 2/4 | 4/4 | 12.8 | |||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 4/4 | 4/4 | 4/4 | 11.3 | |||
| Capless | / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 2/4 | 4/4 | 4/4 | 4/4 | 4/4 | 10.0 | ||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 1/4 | 4/4 | 4/4 | 12.2 | |||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 4/4 | 4/4 | 4/4 | 4/4 | 4/4 | 9.5 | |||
| 56 | Capped | / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 2/4 | 3/4 | 4/4 | 12.0 | 0.07 |
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 2/4 | 2/4 | 4/4 | 12.5 | |||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 2/4 | 3/4 | 4/4 | 12.2 | |||
| Capless | / | 0/4 | 0/4 | 0/4 | 1/4 | 1/4 | 2/4 | 4/4 | 4/4 | 4/4 | 4/4 | 4/4 | 8.6 | ||
| / | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 0/4 | 1/4 | 2/4 | 4/4 | 4/4 | 4/4 | 10.8 | |||
| / | 0/4 | 0/4 | 0/4 | 2/4 | 3/4 | 3/4 | 4/4 | 4/4 | 4/4 | 4/4 | 4/4 | 7.5 | |||
| BVDV-infected ctrl | 4/4 | positive | |||||||||||||
| BVDV-uninfected ctrl | 0/4 | negative | |||||||||||||