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. 2024 Aug 29;19:63. doi: 10.1186/s13024-024-00751-7

Fig. 2.

Fig. 2

APOE jxn1.2.2 transcript is associated with Alzheimer’s disease (AD). A jxn1.2.2 expression (red) is the top hit compared to other transcripts at the APOE locus (blue) in the ROSMAP brain DLPFC region. The association of AD risk SNP, rs157580, with APOE gene level and its 3 transcripts (jxn1.2.1, jxn1.2.2, and jxn1.2.3) in ROSMAP considering global ancestry (B). Association of jxn1.2.2 and AD risk SNP in LIBD European ancestry (C) and African American (D). E Local ancestry analysis at the APOE locus