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. 2024 Aug 29;19:63. doi: 10.1186/s13024-024-00751-7

Fig. 5.

Fig. 5

Candidate SNPs at the APOE locus located within active chromatin affect transcriptional factors (TFs)’ binding affinity. Left panel: (A) rs439401, (B) rs1871046, and (C) rs157580 are co-localized with H3K9ac ChIP-seq peak from human postmortem brains. Right panel: Recognition sites of TFs involved in Alzheimer’s disease are influenced by the 3 SNPs. The red dash box indicates the binding site of each SNP. D Linkage disequilibrium of candidate SNPs with other SNPs spanning APOE, including the two APOE2,3,4-determining SNPs