FIG 3.

Summary schema of immune correlative results. This figure summarizes peripheral blood immune subset and functional marker changes by CaboNivo and CaboNivoIpi treatments and association with PFS and OS. CaboNivo and CaboNivoIpi treatments had common and differential impacts on immune subsets. In brief, myeloid cells, including M-MDSC, classical monocytes, and dendritic cells, decreased by both treatments, but association with OS was observed only in CaboNivoIpi treatment group. The activated (Ki67+HLA-DR+, Ki67+ICOS+, or Ki67+GITR+) T cells were robustly increased by CaboNivoIpi treatment; however, association with PFS and OS was observed mostly in the CaboNivo treatment group. The associations with PFS and OS are denoted with (a, b) in the CaboNivo group and with (c, d) in the CaboNivoIpi group. EM, effector memory cells; eTreg, effector regulatory T cells; M-MDSC, monocytic myeloid-derived suppressor cells; mDC, myeloid dendritic cells; OS, overall survival; pDC, plasmacytoid dendritic cells; PFS, progression-free survival.