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Effect on CTLA-4 and TIM-3 expression. Expression of CTLA-4 on (A) CD4+ T cells and on (B) CD8+ T cells increased with both CaboNivo and CaboNivoIpi. Expression of TIM-3 on (C) CD4+ T cells and on (D) CD8+ T cells increased with both treatments. Higher expression of CTLA-4 on CD4+ T cells at (E, F) C2D1 and at (G, H) C3D1 was associated with improved PFS and OS. OS, overall survival; PFS, progression-free survival.
