Fig 6. Current working model of interaction between DUF490 and the BAM complex in Borreliella burgdorferi.

The B. burgdorferi TAM-BAM system based on combined interaction data and AlphaFold v2.0 modeling of each protein. BamA POTRA1-3 and DUF490 were modeled as a multimer and combined with the remainder of their structures. BamA is depicted in red, BamB depicted in blue, BamD depicted in yellow, TamB (aa 1–1116) depicted in mint green, and DUF490 (aa 1117–1443) depicted in dark green. The depicted membrane is a general representation of the borrelial membrane. Diacylated gray molecules represent phospholipids. Diacylated orange molecules represent glycolipids. Triacylated globular proteins represent other lipoproteins, pink squares represent metabolite transporters, green channels represent ABC transporters, and gray barrels represent porins. Created with BioRender.com.