Extended Data Fig. 3: Expression changes of the m⁶A “writer” core components in sporadic ALS iPSNs.

a, Proteomic heatmap of the core components of m6A “writer” complex in control (n=19) and sporadic ALS (n=93) iPSNs. Data were normalized to the batch controls. b, Boxplots of the proteomic data in (a). Box plots indicate the interquartile range with the central line representing the median, and the vertical lines extend to the extreme values in the group. c, UHPLC-QQQ-MS/MS quantification of the m⁶A/A ratio in poly-A mRNAs from control (n=5) and sporadic ALS patient (n=7) postmortem frontal cortex. Data are mean ± s.e.m. Points represent individual samples. *p=0.0247 by two-tailed t test.