Table 3. Summary of predinical studies on the use of CAR-T cells co-expressing cytokines in the treatment of malignant tumors.

Tumor	Targeted antigen	Gene-edited cytokines
Glioblastoma, ovarian cancer and pancreatic cancer	CD70	IL-8andCXCR1orCXCR2 [180]
All or hepatocellular carcinoma	CD19,GPC3	IL-9 [181]
Lung cancer, pancreatic ductal adenocarcinoma	hCD20 Mesothelin	IL-7 and CCL19
prostatic cancer	NKG2D	IL-7
hepatic carcinoma	GPC3	IL-7 and PH20
breast carcinoma	AXL	C7R
Colorectal cancer, pancreatic cancer, stomach cancer CEA	GEA	IL-12
lymphoma	CD19	IL-12
hepatic carcinoma	glypican-3 (GPC3)	IL-12
ovarian cancer	Muc-16	IL-12
leukemia	CD19	IL-15
Cerebral endothelioma	VEGFR-2	IL-15
melanoma	CD19	IL-18
hepatic carcinoma	GPC3	IL-21
chronic lymphocytic leukemia	CD19	IL-21
hepatic carcinoma	GPC3	IL-15 and IL-21
neuroblastoma	GD2	IL-23
prostatic cancer	PSMA	IL-23