Extended Data Fig. 7. Impact of TGFβ signalling inhibition on HBV pol455-specific CD8⁺ T cell function.

(a) Dot plots showing IFNγ-, TNF and CD107a-producing HBV pol₄₅₅-specific CD8⁺ T cells in response to peptide stimulation after 14 days of in vitro culture with (left) and without TGFβ RI Kinase Inhibitor II (middle). Negative control is depicted on the right. The percentages of IFN-γ-, TNF and CD107a-producing HBV pol₄₅₅-specific CD8⁺ T cells were determined in relation to the frequency of HBV pol₄₅₅-specific CD8⁺ T cells for individuals with endogenous control/chronic HBV. (b) The polyfunctionality of HBV pol₄₅₅-specific CD8⁺ T cells were assessed by gating on IFN-γ and TNF positive cells. Each dot represents one of the respective HBV pol₄₅₅-specific CD8⁺ + T cell responses with color coding as indicated: dark green, endogenous control/chronic HBV, n = 6. Statistical analyses were performed via two-tailed Wilcoxon matched-pairs signed rank test (a,b).

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