Table 1.
Human PHD2 serum protein levels are positively correlated with metabolic syndrome related traits
| Model* | Outcome variable | N | β coef. | 95% CI | S.E. | P value |
|---|---|---|---|---|---|---|
| Linear regression | ||||||
| Body mass index, kg/m2 | 5439 | 0.356 | (0.234, 0.478) | 0.062 | 1.17E-08 | |
| Visceral fat area, cm2 | 5228 | 8.220 | (6.085, 10.355) | 1.089 | 5.20E-14 | |
| Triglyceride serum, mmol/L | 5447 | 0.066 | (0.048, 0.084) | 0.009 | 6.33E-13 | |
| Fasting glucose, mmol/L | 5447 | 0.063 | (0.031, 0.095) | 0.016 | 1.05E-04 | |
| HbA1c, g/dl | 5019 | 0.009 | (0.006, 0.012) | 0.001 | 4.22E-11 | |
| Insulin serum, µU/ml | 5446 | 1.127 | (0.832, 1.422) | 0.150 | 7.36E-14 | |
| Logistic regression | ||||||
| Type II diabetes | 5447 | 1.191 | (1.094, 1.297) | 0.052 | 5.76E-05 | |
| IFG (5.6–6.9 mmol/L) | 4787 | 1.057 | (0.994, 1.124) | 0.033 | 7.53E-02 | |
| Metabolic syndrome | 5443 | 1.260 | (1.186, 1.340) | 0.039 | 9.71E-14 | |
N number of individuals with outcome data, CI confidence intervals, S.E. standard error, IFG impaired fasting glucose.
*Models were adjusted for PHD2, age and sex. PHD2 beta coefficients for continuous outcome variables are from a linear regression. For dichotomous outcome variables the PHD2 beta coefficients are odds ratios from logistic regression (see “Methods” for more details on the summary statistics). P values are two-sided.
Serum protein PHD2 levels were correlated with BMI, visceral adiposity, triglycerides, fasting glucose, HBA1C, insulin, type II diabetes and metabolic syndrome in the population-based Age, Gene/Environment Susceptibility (AGES) study.