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. 2024 Aug 22;15(4):93606. doi: 10.4291/wjgp.v15.i4.93606

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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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The FXR-controlled gene regulation network. The main biological functions regulated by FXR are indicated on the right[117]. Genes upregulated by FXR are indicated by green arrows, and those that are downregulated by red arrows. Indirect regulation modes are indicated on the right, underlining the important role of SHP in this pathway. When known, the intermediate signaling molecule or the component(s) of the signaling cascade are indicated. Species-specific regulation is mentioned when known (h, human; Rb, rabbit). When known, the type of FXRE is indicated. IR: Inverted repeat; DR: Direct repeat; ER: Everted repeat. Citation: Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009; 89: 147-191. Copyright © The American Physiological Society 2009. Published by The American Physiological Society.