Figure 5.

Bulk RNA-seq analysis of tumor tissues. (A) Potentially increased and decreased abundance of cell types at indicated time points after 5DEX-0509R administration (n = 3). Estimated intratumoral abundance (scores) for each cell type in compound-treated tumors was compared to scores in vehicle-treated tumors. Significantly increased or decreased abundance scores for cell types (q < 0.25, two-sided Welch t-test) are shown as red or blue points. (B) Abundance scores for representative, significantly changed cell types. (C–E) Expression levels of representative marker genes for macrophages (C), T cells (D), and B cells (E). Asterisk denotes significant (q < 0.25) changes compared to the vehicle by the two-sided Welch t-test.