Figure 3. Effect of proximal tubule-specific angiotensinogen (AGT) KO (PKO) and liver-specific AGT KO (LKO) in unilateral ureteral obstruction (UUO)-induced kidney tubular injury and fibrosis. WT control, PKO, and LKO mice were subjected to UUO or sham operation for seven days. (A) Paraffin-embedded kidney sections were used for PAS staining (n=6-7). (B) Ratios of atrophied and dilated tubule to total tubules were evaluated as described in the Methods section. Insets indicate atrophied tubule. Scale bar, 50 μm. Data are expressed as means±SD. *p<0.05 vs. WT-Sham.
