Table 1.

The top 10 most significantly altered rRFs

Gene	Start position	End position	Length	Sequence (5′-to-3′)	Corresponding license plate	Healthy		COPD		Log2 FC	FDR
						Av. RPM	SD	Av. RPM	SD
18S	1274	1296	23	GGACACGGACAGGATTGACAGAT	rRF-23-6FMD1EXFD7	6124.781	4849.117	6.104	2.713	−10.154	9.457 × 10−56
28S	266	289	24	CGGGTCTTCCCGGAGTCGGGTTGC	rRF-24-M3NRM0WKKM	372.489	190.429	5.574	2.032	−6.440	1.683 × 10−21
28S	1939	1986	48	AGAAAAGGTGTTGGTTGATAT AGACAGCAGGACGGTGGCCATGGAAGT	rRF-48-FB14Z3XLVDFPO891I2Z	5805.049	4133.487	93.199	52.723	−6.282	6.354 × 10−19
18S	1269	1296	28	GGCCCGGACACGGACAGGATTGACAGAT	rRF-28-6R6FMD1EXFD7	361.224	227.589	3.173	2.791	−7.127	8.179 × 10−19
18S	1265	1296	32	ACCCGGCCCGGACACGGA CAGGATTGACAGAT	rRF-32-0SPSO56F6NOPI	635.546	498.004	3.706	2.857	−8.203	5.004 × 10−15
28S	1939	1980	42	AGAAAAGGTGTTGGTTGATAT AGACAGCAGGACGGTGGCCAT	rRF-42-FB14Z3XLVDFPO891I	329.882	169.131	9.239	6.928	−5.476	8.037 × 10−15
28S	2016	2044	29	CACCTGCCGAATCAACTAGCCCTGAAAAT	rRF-29-27PUHO4J3U07	236.606	49.282	26.795	14.418	−3.461	1.706 × 10−13
28S	4859	4895	37	CGGGGTCCGGTGCGGAGTGC CCTTCGTCCTGGGAAAC	rRF-37-MK88X81V39S7RB1	648.246	499.817	0.876	0.668	−10.179	3.448 × 10−13
18S	1522	1542	21	ACGCGCGCTACACTGACTGGC	rRF-21-EHLX2YE8D	299.667	181.965	2.209	2.034	−7.593	4.095 × 10−13
28S	2049	2090	42	GGCGCTGGAGCGTCGGGCCCATA CCCGGCCGTCGCCGGCAGT	rRF-42-6V90MS6RH1M1SVMFN	267.977	184.440	3.689	1.985	−6.900	9.650 × 10−13

The rRFs with a difference of only one nucleotide in their start or end positions have been excluded from the list. Av. = average.