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Long-term follow up of patients with nmCSPC (NCT00582140). Patients were followed for 15 y for significant medical events. Shown are the times at which patients developed documented metastatic disease (■), started androgen deprivation therapy (red), started a second generation AR targeted therapy (brown), or started docetaxel (blue). The time of death due to prostate cancer (●) or other cause (▲) is also shown. Subjects are ordered with respect to the pre-treatment PSA doubling time.
