Figure 4.

Long-term T cell immune response to PAP target antigen detectable after immunization. PBMCs from patients with nmCSPC (n = 10, panel A) or nmCRPC (n = 5, panel B) obtained within days pre-treatment, at the end of the vaccination period, and at late time points years later were evaluated by ELISPOT for IFNγ release in response to PAP antigen stimulation. pap-specific spot-forming units (sfu) shown are the mean among 6 replicates, and subtracted for contribution from media alone. Circles indicate non-significant difference from media alone control, and star shapes represent those significantly different from media alone. Colors correspond to individual subjects.