Table 1.
Overview of the correlation between A. muciniphila and IBD in the past three years.
| Study types | Model | Subject | Sample types | Analysis method | Result characteristics | Reference |
|---|---|---|---|---|---|---|
| Animal | DSS‑induced colitis | 7-weeks old C57BL/6J mice | Feces | 16S rRNA | Stable colonization of live A. muciniphila is essential for its anti-inflammatory function. | Wang et al. 2023 [67] |
| Animal | DSS‑induced colitis | 6-weeks old male C57BL/6J mice | Colon contents | 16S rRNA | A. muciniphila alleviates the symptoms of colitis in mice. | Xue et al. 2023 [68] |
| Animal | DSS‑induced colitis | CREBH-KO mice | Ileum and colon tissues | qRT‑PCR | A. muciniphila ameliorates intestinal inflammatory in DSS‑induced colitis mice. | Wade et al. 2023 [66] |
| Animal | TNBS-induced IBD | 6-8 weeks old male BALB/c mice | Feces | 16S rRNA | The abundance of A. muciniphila was decreased in the TNBS-treated mice. | Chang et al. 2022 [46] |
| Animal and human | DSS‑induced colitis and UC | TLR4-knockout C57BL/6 mice and UC patients | Feces | 16S rRNA | The abundance of A. muciniphila was negatively to colitis risk. | Liu et al. 2022 [47] |
| Human | UC and Crohn’s diseases | UC and Crohn patients | Feces and blood | RT-PCR | Relative abundance of A. muciniphila was significantly lower in IBD. | Sezgin et al. 2022 [73] |
| Human | UC and IBS | UC and IBS patients | Feces | qPCR | The level of A. muciniphila reduced in patients with UC from HPRs. | Dorofeyev et al. 2022 [72] |
| Animal | TNBS-induced IBD | 6–8 weeks old male BALB/c mice | Feces | 16S rRNA | The abundance of A. muciniphila was degraded in the TNBS-treated mice but elevated in the PAW-drinking mice. | Chang et al. 2022 [46] |
| Animal | DSS‑induced colitis | 5-6 weeks old male C57BL/6 mice | Feces | 16S rRNA | Amuc_2109 secreted by A. muciniphila reshaped the intestinal microbiota. | Qian et al. 2022 [69] |
| Animal and human | DSS‑induced colitis and UC | 6-weeks old male C57BL/6 mice and UC patients | Feces | 16S rRNA | The level of A. muciniphila was decreased UC patients and A. muciniphila showed the protective effect in colitis. | Qu et al. 2021[63] |
| Animal | DSS‑induced colitis | C57BL/6 mice | Feces | 16S rRNA | A. muciniphila showed a positive effect on UC. | Liu et al. 2021 [65] |
| Animal | DSS‑induced colitis | 6-weeks old male Wistar/ST rats | Feces | 16S metagenomics | Antibacterial (OPS-2071) increased the occupancy of A. muciniphila in the DSS-treated rats. | Nakashima et al. 2021 [120] |
| Animal | DSS-induced UC | 6-8 weeks old male C57BL/6 mice | Feces | 16S rRNA | The level of A. muciniphila was increased after metformin treatment. | Ke et al. 2021 [118] |
| Animal | DSS‑induced colitis | GPR43-knockout mice | Feces | 16S rRNA | The level of A. muciniphila was increased after lithium carbonate treatment. | Huang et al. 2021 [177] |
Note: ulcerative colitis (UC), colitis-associated colorectal cancer (CAC), irritable bowel syndrome (IBS), colorectal cancer (CRC), highly polluted with PM2.5 (HPRs), 2,4,6-trinitrobenzene sulphonic acid (TNBS), Plasmon-activated water (PAW).