Table 2.
Summary the research on the role of A. muciniphila in obesity and diabetes mellitus in the past three years.
| Type of study | Diseases condition | Sample type | Analysis method | Result characteristics | Reference |
|---|---|---|---|---|---|
| Animal | HFD induced obesity | Feces | 16S rRNA | The abundance of A. muciniphila in mice treated with D3 increased about 100 times, compared with the HFD mice. | Li et al. 2023 [97] |
| Human | Obesity | Feces | 16S rRNA | The abundance of A. muciniphila in the treatment group was increased. | Cao et al. 2023 [101] |
| Animal | Obesity | Feces | 16S rRNA | The abundance of A. muciniphila was increased in mice fed milk and the FMT group from the mice fed milk. | Okamura et al. 2023 [102] |
| Animal | HFD induced obesity | Feces | 16S rRNA | The level of A. muciniphila was elevated in obese mice after administration of E. cristatum. | Wang et al. 2023 [105] |
| Animal | HFD induced obesity | Feces, feces contents | 16S rRNA | The level of A. muciniphila was increased after IX treatment in obese mice. | Watanabe et al. 2023 [94] |
| Animal | HFD induced obesity | Feces | 16S rRNA | The mice challenged with HFD and treated with VCM had large amounts of A. muciniphila in their ileum and cecum. | Sonomoto et al. 2023 [95] |
| Animal | Diet-induced obesity | Feces | 16S rRNA | A. muciniphila showed significant improvement in body weight, total fat weight. | Kumar et al. 2022 [106] |
| Animal | HFHS-induced obesity | Feces | 16S rRNA qPCR |
The level of A. muciniphila was significantly increased in obese mice treated with AG and GSE. | Watanabe et al. 2022 [99] |
| Animal | HFD induced obesity | Feces | 16S rRNA RT-qPCR |
A. muciniphila controls weight gain and increases the Firmicutes/Bacteroidetes (F/B) ratio. | Lin et al. 2022 [171] |
| Animal | HFD induced obesity | Feces | 16S rRNA | A. muciniphila were significantly increased after a combined supplement of three probiotic strains. | Liao et al. 2022 [103] |
| Animal | HFD induced obesity | Feces | 16S rRNA | The abundance of A. muciniphila was increased in HFD mice after EPA treatment. | Pal et al. 2022 [184] |
| Animal | HFD induced obesity | Feces | 16S rRNA | Supplemented with A. muciniphila prevented HFD-induced body weight gain, fat mass gain. | Acharya et al. 2022 [107] |
| Animal | HFD induced obesity | Feces | 16S rRNA | The relative abundance of resident A. muciniphila was increased in HFD mice after PMGs treatment. | Pruss et al. 2021 [100] |
| Human | Obesity | Feces | Metagenomic sequencing | After weight loss, the abundance of A. muciniphila was significantly increased. | Alili et al. 2021 [98] |
| Animal | HFD induced obesity | Feces | 16S rRNA RT-PCR |
A. muciniphila could avoid HFD induced dysbiosis by decreasing obesity-related pathobiont bacteria and increasing health-related gut microbiota. | Ashrafian et al. 2021 [115] |
| Animal | HFD induced obesity | Feces | 16S rRNA | With LA5 administration, A. muciniphila in the colon were more than 2,000 folds higher than the regular diet mice. |
Ondee et al. 2021 [104] |
| Animal | HFD induced obesity | Feces | 16S rRNA | Supplementation with betaine increase the level of A. muciniphila in HFD mice. | Du et al. 2021 [96] |
| Human | Obesity | Feces | Metagenomic sequencing | A. muciniphila was significantly enriched in lean individuals, and its abundance increased during dieting. | Jie et al. 2021 [92] |
| Animal | HFD induced obesity | Intestinal tissues | RT-PCR | Live and pasteurized forms of A. muciniphila improved the HFD-induced obesity and metabolic dysregulation in mice. | Choi et al. 2021 [111] |
| Human | Obesity | Feces | 16S rRNA | The abundance of A. muciniphila was enhanced in the postop group. | Shi et al. 2021 [93] |
| Animal | T2DM | Intestines sample | 16S rRNA | Intestinal health of TA zebrafish was improved with pasteurized A. muciniphila. | Qu et al. 2023 [133] |
| Animal | T2DM | Feces | 16S rRNA RT-qPCR |
Metformin led to a significant increase in the abundance of A. muciniphila in mice. | Ye et al. 2023 [132] |
| Animal | Diabetes | Feces | 16S rRNA | Compared to the control group, treatment with A. muciniphila significantly increased serum insulin and GLP-1 level. |
Wang et al. 2023 [131] |
| Human | T2DM | Feces | qPCR | In T2D patients with high HOMA-IR and BMI, there was a low abundance of A. muciniphila. | Pai et al. 2022 [128] |
| Human | T2DM | Feces | qPCR | The abundance of A. muciniphila was decreased in patients with type1 and increased in type2 diabetes. | Demirci et al. 2022 [127] |
| Human | T2DM | Feces | Metagenomic sequencing | The abundance of A. muciniphila significantly decreases in lean individuals with T2D than without T2D. | Zhang et al. 2021 [135] |
| Human | Diabetes | Feces | RT-PCR | Compared with control group, A. muciniphila was significantly lower in diabetic. | Tabasi et al. 2021 [129] |
| Animal | T2DM | Colonic contents | 16S rRNA | The DFs significantly improved the relative abundance of A. muciniphila on diabetic mice. | Li et al. 2021 [124] |
Note: Faecal microbiota transplantation (FMT), Eicosapentaenoic acid (EPA), Lactobacillus acidophilus 5 (LA5), Capsanthin (CAP), High-fat diet (HFD), high-fat, high-sucrose (HFHS), Zebrafish with combined T2DM and Alzheimer’s disease (TA zebrafish), Scutellaria baicalensis (SB), arctigenin (AG), burdock sprout extract (GSE), vancomycin (VCM), Eurotium cristatum (E. cristatum), Isoxanthohumol (IX), porcine mucin glycans (PMGs), dietary fibers (DFs).