Fig. 6. Enrichment factors for DUD-E targets at 0.1% library.

(A) Fold enrichment into true positives, defined as the ratio of true-positive fraction for full versus reduced library for AutoDock (blue) versus ceSAR-S (red) and consensus methods ceSAR-C₁ (yellow) and ceSAR-cML₁ (green). (B) The number of targets with ≥5-fold enrichment versus limited or no enrichment (gray) at 0.1% library reduction. Note that ceSAR approaches are more robust and consensus methods ceSAR-C₁ and ceSAR-cML₁ significantly outperform docking (P = 0.02), reducing the number of targets with limited or no enrichment to four while greatly reducing the computational cost. Statistically significant differences are indicated by arrows with asterisks (*) in (B).