Fig. 2.

The specific response of DPDOs to AURKi Barasertib-HQPA and Danusertib. (a) In HE staining of PDOs slice, four DPDOs shows the morphology of DGC without obvious glandular structure and poorly adhesive arrangement. (b) Compared to NC group, the cell diameter of Danusertib group or Barasertib-HQPA group is significantly increased, with no cell lysis and necrosis. (c) By Danusertib and Barasertib-HQPA treatment (1 μΜ, 96 h), the cell diameter of four DPDOs is significantly increased compared to NC group, n = 10，scale bar = 30 μm; **P < 0.01; ***P < 0.001.