Fig. 2. Diversity and composition of ARGs in viral genomes.

Number of ARG types detected in the genomes of different taxonomic groups in (A) NCLDVs and (B) phages. Data are presented as mean values ± SEM. The unit of study is one genome. The number (n) of genomes in each group can be found in Supplementary Data 7 for (A) and Supplementary Data 8 for (B). Lower-case letters above the bars represent significantly different groups assessed with two-sided Wilcoxon rank-sum test, and P-values indicate the overall difference among all families assessed with Kruskal–Wallis test. Composition of ARG types in different families in (C) NCLDVs and (D) phages. Composition of ARG resistance mechanisms in different families in (E) NCLDVs and (F) phages. For clarity, only viral families with more than five ARGs, the unclassified genomes (as a whole), and the overall patterns of NCLDVs and phages are displayed. MLS is the abbreviation of macrolides, lincosamides, and streptogramines. Source data are provided as a Source Data file on Github¹⁰⁷.