Table 1.
Most prevalently detected antimicrobial resistance gene families in nucleocytoplasmic large DNA virus (NCLDV) and phage genomes
| AMR gene familya | ARG type | Mechanism | No. detected in NCLDVs | No. detected in phages |
|---|---|---|---|---|
| trimethoprim resistant dihydrofolate reductase dfr | trimethoprim | antibiotic target replacement | 303 | 325 |
| F-subtype ATP-binding cassette protein | multiple antibiotics | antibiotic target protection | 219 | 46 |
| antibiotic-resistant isoleucyl-tRNA synthetase (ileS) | mupirocin | antibiotic target alteration | 52 | 0 |
| streptogramin vat acetyltransferase | MLS | antibiotic inactivation | 27 | 5 |
| glycopeptide resistance gene cluster;vanH | glycopeptide | antibiotic target alteration | 24 | 6 |
| glycopeptide resistance gene cluster;vanT | glycopeptide | antibiotic target alteration | 20 | 0 |
| tetracycline-resistant ribosomal protection protein | tetracycline | antibiotic target protection | 16 | 5 |
| pmr phosphoethanolamine transferase | polymyxin | antibiotic target alteration | 12 | 9 |
| glycopeptide resistance gene cluster;vanS | glycopeptide | antibiotic target alteration | 11 | 2 |
aAMR gene families were adopted from CARD database. AMR gene families with more than 10 ORFs detected in NCLDVs were shown.