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Impact of SiMPs on secondary structure of immunoglobulin and albumin proteins. Far-UV CD spectra were measured to evaluate the secondary structure of (A) IVIG-SiMPs, (B) HSA-SiMPs, and (C) IgG-SiMPs samples in comparison with their respective control proteins IVIG and HSA. (D) Near-UV CD data (left) and complementary absorbance spectra (right) of IVIG-SiMPs samples shown versus control IVIG. Abbreviation used: sup, supernatant; sed, sediment; ctrl, control
