Table 1.

Summary of Embedded Psychosocial Studies (PSS)

Aim	To understand patients’, parents’, and health professionals’ perspectives, experiences and support/training needs
	ZERO PROGRAM
Study	PRISMa	ZERO2b	PREDICTc	SMOC-Juniord
Testing and surveillance offered	Germline and somatic sequencing as part of a precision medicine program	Germline and somatic sequencing as part of a precision medicine program	Trio-based genomic sequencing to diagnose cancer predisposition	Surveillance involving WB-MRI
Patient population	Children (age < 21) with poor prognosis cancer at diagnosis, relapse, progression	Children (age < 25) with cancer at diagnosis, relapse, progression	Children (age < 21) with cancer at diagnosis	Children (age < 18) with a cancer predisposition syndrome
PSS participants	Patients (age ≥ 12), parents, health professionals			Patients (age ≥ 12) and parents
PSS methods	Longitudinal, mixed methods

^aThe PRecISion Medicine for Children with Cancer (PRISM) study.

^bZERO2, the Next iteration of the PRISM study expanded to all diagnoses.

^cThe cancer PREDisposition In Childhood by Trio-based whole-genome sequencing (PREDICT) study.

^dSurveillance study in Multi-Organ Cancer predisposition syndromes in pediatrics (SMOC-Junior).