Comparison 1. Systolic blood pressure.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Total mortality	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2 Cardiovascular mortality	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3 Non‐CV mortality	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4 Total serious adverse events	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5 Myocardial infarction	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6 Stroke	1		Risk Difference (M‐H, Fixed, 95% CI)	Subtotals only
7 Congestive heart failure	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8 End‐stage renal failure	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
9 All other serious adverse events	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
10 Systolic blood pressure achieved	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
11 Diastolic blood pressure achieved	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
12 Withdrawals due to adverse events	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
13 Number of antihypertensive drugs needed per patient	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only