Outcome	Studies	Participants	Statistical method	Effect estimate	P
Total mortality	4	2079	Risk Ratio (M‐H, Fixed, 95% CI)	0.64, 95% CI 0.45 to 0.92	0.02
Cardiovascular mortality	3	1950	Risk Ratio (M‐H, Fixed, 95% CI)	0.64, 95% CI 0.39 to 1.03	0.07
Non‐cardiovascular mortality	3	1950	Risk Ratio (M‐H, Fixed, 95% CI)	0.62, 95% CI 0.35 to 1.08	0.09
Total serious adverse events	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	Not estimable
Myocardial infarction	4	2079	Risk Ratio (M‐H, Fixed, 95% CI)	0.98, 95% CI 0.65 to 1.48	0.93
Stroke	4	2079	Risk Ratio (M‐H, Fixed, 95% CI)	0.64, 95% CI 0.39to 1.06	0.08
Congestive heart failure	2	950	Risk Ratio (M‐H, Fixed, 95% CI)	1.06, 95% CI 0.58 to 1.92	0.86