Table 2.
Biophysical Properties of hERG and hERG-BZF Channels Before and After UV Irradiation in the Open State
| State: open | ||||||||
|---|---|---|---|---|---|---|---|---|
| Channel | hERG | hERG | hERG-G47BZF | hERG-G47BZF | hERG-F48BZF | hERG-F48BZF | hERG-E50BZF | hERG-E50BZF |
| UV irradiation time (sec) | 0 | 15 | 0 | 15 | 0 | 15 | 0 | 15 |
| V0.5 (mV) | −42 ± 3 | −40 ± 3 | −48 ± 0.4 | −44 ± 2 | −49 ± 1 | −37 ± 1 | −39 ± 1 | −35 ± 3 |
| Tau fast (ms) | 45 ± 3 | 44 ± 1 | 38 ± 6 | 16 ± 1 | 35 ± 3 | 21 ± 1 | 37 ± 2 | 34 ± 2 |
| Time to half max (sec) | 0.59 ± 0.01 | 0.59 ± 0.01 | 0.55 ± 0.01 | 0.55 ± 0.01 | 0.51 ± 0.04 | 0.64 ± 0.03 | 0.58 ± 0.03 | 0.58 ± 0.03 |