Skip to main content
. 2024 Aug 30;12:92. doi: 10.1186/s40364-024-00641-6

Fig. 6.

Fig. 6

Mechanisms of hepatic fibrosis involved in BRD4 and anti-hepatic fibrosis effects and mechanisms of BRD4 inhibitors. BRD4 is involved in fibrotic phenotypic changes in hepatic stellate cells (HSCs), epithelial cells, macrophages and hepatocytes caused by external stimuli. It mainly affects the expression of fibrosis-related genes. BRD4 inhibitors (JQ1, Compound 38, SAA) exert their anti-hepatic fibrosis effects mainly by inhibiting BRD4-mediated gene transcription, activation of HSCs, and expression of inflammatory factors