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Mechanisms of renal fibrosis involved in BRD4 and anti-renal fibrosis mechanisms of BRD4 inhibitors. BRD4 is involved in the fibrotic phenotypic changes in tethered cells and parietal epithelial cells caused by external stimuli. BRD4 inhibitors (JQ1, I-BET151, ZLD2218, and MS417) mainly inhibit BRD4-mediated gene transcription and oxidative stress to exert anti-renal fibrosis effects
