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. 2024 Mar 9;14(8):3680–3696. doi: 10.1016/j.apsb.2024.03.010

Figure 1.

Figure 1

Chemical structures and characterizations of Epi-PD. (A) Molecular structures and Coarse-Grained models of Epi-P1D, Epi-P2D, and Epi-P4D. (B) The self-assembly processes of nanomedicine formation from Epi-P1D, Epi-P2D, and Epi-P4D. (C) Transmission electron microscopy (TEM) images and (D) hydrodynamic size distributions of Epi-P1D, Epi-P2D, and Epi-P4D. (E) Fluorescence emission spectra of Epi·HCl, Epi-P1D, Epi-P2D, and Epi-P4D in H2O at an equivalent Epi concentration excited at 480 nm. (F) Size variations of Epi-P1D, Epi-P2D, and Epi-P4D in H2O for up to 42 weeks (data are mean ± SD, n = 3). In vitro Epi release profiles from (G) Epi-P1D, (H) Epi-P2D, and (I) Epi-P4D in phosphate-buffered saline (PBS, pH 7.4, 6.5, and 5.0) within 72 h (data are mean ± SD, n = 3).