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. 2024 Mar 9;14(8):3680–3696. doi: 10.1016/j.apsb.2024.03.010

Figure 8.

Figure 8

Modulation of the tumor immune microenvironment. (A) Flow cytometry diagrams and (B) quantitative results of natural killer (NK) T cells (CD45+CD3+CD49b+) and (C) NK cells (CD45+CD3−CD49b+) in the tumors of the CT26 tumor-bearing mice after treatment with Epi·HCl, Epi-P1D, Epi-P2D, or Epi-P4D (Data are mean ± SD, n = 3). (D) Flow cytometry analysis and (E) statistical results of activated (NKG2D+) NK cells (Data are mean ± SD, n = 3). (F) Flow cytometry analysis of CD4+ T cells (CD45+CD3+CD4+) and CD8+ T cells (CD45+CD3+CD8+) in the tumors after different treatments. (G) Illustration of changes in the populations of immune cells in the tumor after treatment with Epi-P4D. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 compared with the Epi-P4D-treated group.