Figure 5. Validation results for previously untested kinase inhibitors.

(A) Comparison between the measured cell viability values and the predicted probability of that experiment yielding a cell viability value below 90%. The blue line shows a loess fit through the data. (B) ROC and PRC curves for the validation data set thresholded at 90% viability. (C) ROC and PRC curves for each of the validation compounds tested (n = 3 technical replicates, n = 2 biological replicates). Dashed lines represent performance for random guessing.