Fig. 1. SQA and OXM analogues inhibit CCL20-mediated activation of CCR6 and display additive binding stabilization to the receptor.

a Chemical structures of SQA1, OXM1 and OXM2. b Inhibition of CCL20-mediated CCR6⁺ human T-cell chemotaxis demonstrated by SQA1 (pIC₅₀ = 6.7 ± 0.8), OXM1 (pIC₅₀ = 6.8 ± 0.2), and OXM2 (pIC₅₀ = 6.78 ± 0.11). Data are presented as mean ± s.d. from n = 3 independent experiments. c,d Thermal shifts of c, WT and d, thermostabilized CCR6 Nα7.1 from Apo to liganded conditions as indicated. Data are presented as mean ± s.d. from n = 4 (WT) and n = 6 (Nα7.1) independent experiments. p value presented in c and d is two-sided from unpaired t test, p < 0.05 was considered significant. Source data are provided as a Source Data file.